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搜索结果

Search Results for " selectin e "
Targets Recommended: Integrin

7

抑制剂 & 化合物

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天然产物

20

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T2254 A-205804

Integrin Cytoskeletal Signaling
A-205804 是一种选择性口服有效的先导抑制剂，抑制 E-selectin 和 ICAM-1表达，IC50分别为 20 nM 和 25 nM，可用于慢性炎症疾病的研究。
T13147 ICAM-1-IN-1

Integrin Cytoskeletal Signaling
ICAM-1-IN-1 是选择性的 ICAM-1和 E-selectin 抑制剂，IC50值分别为5和7 nM。
T14573 Bimosiamose disodium

TBC-1269Z

 Integrin Cytoskeletal Signaling
Bimosiamose disodium has anti-inflammatory effects[1]. Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively.
T14574 Bimosiamose

TBC-1269

 Integrin Cytoskeletal Signaling
Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.
T35884 Sialyl-Lewis X

Sialyl-Lewis X (sLeX), a sialylated fucosylated tetrasaccharide and endogenous antigen, serves as a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. It interacts with ELAM-1 and CD62, consequently inhibiting CD62-mediated neutrophil recruitment to inflammation sites[2].
T36221 2-chloro Palmitic Acid

2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endot...
T83825 Trofinetide acetate

NNZ-2566
Trofinetide是一种衍生自具有神经保护作用的三肽Gly-Pro-Glu的化合物，后者是胰岛素样生长因子-1（IGF-1）的N-端序列。在10 nM的浓度下使用时，它能减少由蛋白磷酸酶抑制剂奥卡达酸在原代大鼠胚胎纹状体神经元中引起的细胞死亡。Trofinetide在一种由穿透性弹道样脑损伤引起的大鼠神经炎症模型中减少了编码IL-1β、TNF-α、IL-6和E-selectin的mRNA的脑表达。在通过中脑动脉闭塞（MCAO）引起的大鼠脑损伤模型中，以30和60 mg/kg的剂量给药时，它减少了皮层和纹状体梗塞区域。Trofinetide（每天100 mg/kg）减少了树突棘的数量，并逆转了在fmr1-/-敲除小鼠脆性X综合征模型中的社交识别和情景恐惧条件反射的缺陷，同时也减少了睾丸重量的增加。含有Trofinetide的制剂已被用于治疗Rett综合征。

化合物

A-205804
Cat.No: T2254
Synonym:
Target: Integrin
ICAM-1-IN-1
Cat.No: T13147
Synonym:
Target: Integrin
Bimosiamose disodium
Cat.No: T14573
Synonym: TBC-1269Z
Target: Integrin
Bimosiamose
Cat.No: T14574
Synonym: TBC-1269
Target: Integrin
Sialyl-Lewis X
Cat.No: T35884
Synonym:
Target:
2-chloro Palmitic Acid
Cat.No: T36221
Synonym:
Target:
Trofinetide acetate
Cat.No: T83825
Synonym: NNZ-2566
Target:
Cat. No. Product Name Target Signaling Pathways
TN1163 2'-Hydroxychalcone

Others Others
2'-Hydroxychalcone 是一种药物合成中间体，可用于合成黄酮类化合物。负载在纳米乳液中的2'-Hydroxychalcone 在Danio rerio 模型对副球孢子菌显示出杀真菌活性。2'-Hydroxychalcone 通过负载脂质的Hepg2细胞中的氧化应激诱导细胞毒性。2'-Hydroxychalcone 抑制通过逆转录聚合酶链反应确定的肿瘤坏死因子-α诱导ICAM-1，VCAM-1和E-选择素的稳态转录水平，因此可能会干扰其基因的转录。

天然产物

2'-Hydroxychalcone
Cat.No: TN1163
Synonym:
Target: Others
Species：
Human (12)
Cynomolgus (3)
Mouse (3)
Rat (2)
Expression System：
HEK293 Cells (20)
Tag：
C-His-Avi (10)
C-hFc (5)
C-His (4)
His (1)
Cat. No. Product Name Species Expression System
TMPY-01167 E-Selectin/CD62E Protein, Human, Recombinant (His)

ELAM,selectin E,CD62E,ELAM1,LECAM2,ESEL

 Human HEK293 Cells
E-Selectin/CD62E Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.1 kDa and the accession number is P16581.
TMPY-03519 E-Selectin/CD62E Protein, Cynomolgus, Recombinant (His)

selectin E

 Cynomolgus HEK293 Cells
E-Selectin/CD62E Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.1 kDa and the accession number is G8F370.
TMPY-03729 E-Selectin/CD62E Protein, Rat, Recombinant (hFc)

selectin E

 Rat HEK293 Cells
E-Selectin/CD62E Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 78.8 kDa and the accession number is P98105.
TMPY-02079 E-Selectin/CD62E Protein, Rat, Recombinant (His)

selectin E

 Rat HEK293 Cells
E-Selectin/CD62E Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53 kDa and the accession number is P98105-1.
TMPY-04145 E-Selectin/CD62E Protein, Cynomolgus, Recombinant (hFc)

selectin E

 Cynomolgus HEK293 Cells
E-Selectin/CD62E Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 85.7 kDa and the accession number is G8F370.
TMPY-03369 E-Selectin/CD62E Protein, Mouse, Recombinant (His)

E-selectin,selectin E,CD62E,Elam

 Mouse HEK293 Cells
E-Selectin/CD62E Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60 kDa and the accession number is Q3U5F6.
TMPY-03816 E-Selectin/CD62E Protein, Mouse, Recombinant (hFc)

Elam,selectin E,E-selectin,CD62E

 Mouse HEK293 Cells
E-Selectin/CD62E Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 85.5 kDa and the accession number is Q3U5F6.
TMPK-00349 E-Selectin/CD62E Protein, Human, Recombinant (His & Avi)

ESEL,RP1-117P20.2,CD62E,ELAM,ELAM1,selectin E,E-

Human HEK293 Cells
E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha.E-selectin mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. E-Selectin/CD62E Protein, Human, Recombinant (His & Avi) is expressed in HEK293...
TMPK-00487 E-selectin/CD62E Protein, Cynomolgus, Recombinant (aa 22-554, His)

selectin E,ELAM,ESEL,SELE,E-Selectin,LECAM...

 Cynomolgus HEK293 Cells
E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha.E-selectin mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. E-selectin/CD62E Protein, Cynomolgus, Recombinant (aa 22-554, His) is expressed...
TMPK-00350 E-Selectin/CD62E Protein, Human, Recombinant (His & Avi), Biotinylated

CD62E,ELAM,SELE,selectin E,LECAM2,ESEL,RP1-117P20.2...

 Human HEK293 Cells
E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha.E-selectin mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. E-Selectin/CD62E Protein, Human, Recombinant (His & Avi), Biotinylated is expre...
TMPY-05488 E-Selectin/CD62E Protein, Human, Recombinant (hFc)

CD62E,ESEL,ELAM1,ELAM,selectin E,LECAM2

 Human HEK293 Cells
E-Selectin/CD62E Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 85.4 kDa and the accession number is P16581.
TMPJ-00612 PSGL-1/CD162 Protein, Mouse, Recombinant (aa 42-307, hFc)

CLA,PSGL1,CD162,PSGL-1

 Mouse HEK293 Cells
P-selectin glycoprotein ligand 1 is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. As cell adhesion molecules, multiple studies have shown that PSGL-1/ P-selectin interaction is required for the normal recruitment of leukocytes during inflammatory reactions, and also participates in hemostatic responses. PSGL-1 ...
TMPK-00830 P-Selectin Protein, Human, Recombinant (Avi & His), Biotinylated

FLJ45155,CD62P,GRMP,CD62,P-Selectin,PSEL,GMP140,LEC...

 Human HEK293 Cells
Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation.
TMPK-01424 Peptide Ready HLA-E*01:03&B2M Monomer Protein, Human, MHC (His & Avi)

MHC,HLA-E*01:03,Peptide Ready

 Human HEK293 Cells
HLA-E*01:03&B2M&Peptide ready Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-E*01:03. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01545 HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Monomer Protein, Human, MHC (His & Avi), Biotinylated

sHLA-E,MHC,MHC class I antigen E,HLAE,MHC HLA-E alpha-1,MHC ...

 Human HEK293 Cells
HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...
TMPK-01423 Peptide Ready HLA-E*01:03&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated

MHC,Peptide Ready,HLA-E*01:03

 Human HEK293 Cells
HLA-E*01:03&B2M&Peptide ready Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-E*01:03. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01541 HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi), Biotinylated

QA1,MHC HLA-E alpha-2.1,MHC,HLAE,MHC class I antigen E,MHC H...

 Human HEK293 Cells
HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...
TMPK-01544 HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi)

MHC class I antigen E,HLAE,sHLA-E,QA1,MHC HLA-E alpha-2.1,MH...

 Human HEK293 Cells
HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...
TMPK-01452 HLA-E*01:03&B2M&Peptide (VMAPKTLVL) Monomer Negative Control Protein, Human, MHC (His & Avi)

HLAE,MHC class I antigen E,MHC,QA1,sHLA-E

 Human HEK293 Cells
HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...
TMPK-01514 HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Monomer Protein, Human, MHC (His & Avi)

sHLA-E,MHC class I antigen E,MHC HLA-E alpha-1,MHC,HLAE,QA1,...

 Human HEK293 Cells
HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...

重组蛋白

E-Selectin/CD62E Protein, Human, Recombinant (His)
Cat.No: TMPY-01167
Species: Human
Expression System: HEK293 Cells
E-Selectin/CD62E Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPY-03519
Species: Cynomolgus
Expression System: HEK293 Cells
E-Selectin/CD62E Protein, Rat, Recombinant (hFc)
Cat.No: TMPY-03729
Species: Rat
Expression System: HEK293 Cells
E-Selectin/CD62E Protein, Rat, Recombinant (His)
Cat.No: TMPY-02079
Species: Rat
Expression System: HEK293 Cells
E-Selectin/CD62E Protein, Cynomolgus, Recombinant (hFc)
Cat.No: TMPY-04145
Species: Cynomolgus
Expression System: HEK293 Cells
E-Selectin/CD62E Protein, Mouse, Recombinant (His)
Cat.No: TMPY-03369
Species: Mouse
Expression System: HEK293 Cells
E-Selectin/CD62E Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-03816
Species: Mouse
Expression System: HEK293 Cells
E-Selectin/CD62E Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00349
Species: Human
Expression System: HEK293 Cells
E-selectin/CD62E Protein, Cynomolgus, Recombinant (aa 22-554, His)
Cat.No: TMPK-00487
Species: Cynomolgus
Expression System: HEK293 Cells
E-Selectin/CD62E Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00350
Species: Human
Expression System: HEK293 Cells
E-Selectin/CD62E Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05488
Species: Human
Expression System: HEK293 Cells
PSGL-1/CD162 Protein, Mouse, Recombinant (aa 42-307, hFc)
Cat.No: TMPJ-00612
Species: Mouse
Expression System: HEK293 Cells
P-Selectin Protein, Human, Recombinant (Avi & His), Biotinylated
Cat.No: TMPK-00830
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-E*01:03&B2M Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01424
Species: Human
Expression System: HEK293 Cells
HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01545
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-E*01:03&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01423
Species: Human
Expression System: HEK293 Cells
HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01541
Species: Human
Expression System: HEK293 Cells
HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01544
Species: Human
Expression System: HEK293 Cells
HLA-E*01:03&B2M&Peptide (VMAPKTLVL) Monomer Negative Control Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01452
Species: Human
Expression System: HEK293 Cells
HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01514
Species: Human
Expression System: HEK293 Cells
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